Mega trials

References

1. Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction.  Gruppo Italiano per lo Studio della Streptochinasi nell’Infarto Miocardico  (GISSI). [No authors listed] Lancet. 1986 Feb 22;1(8478):397-402.
2. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. [No authors listed]  Lancet. 1988 Aug 13;2(8607):349-60.
3. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators. [No authors listed] N Engl J Med. 1993 Sep 2;329(10):673-82.
4. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Keeley EC1, Boura JA, Grines CL. Lancet. 2003 Jan 4;361(9351):13-20.
5. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin  Survival  Study (4S) [No authors listed] Lancet. 1994 Nov 19;344(8934):1383-9.
6. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ.  WOSCOPS   N Engl J Med. 1995 Nov 16;333(20):1301-7.
7. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Heart Protection Study Collaborative Group. HPS Lancet. 2002 Jul 6;360(9326):7-22.
8. Cannon CP, Braunwald E, McCabe CH, et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. N Engl J Med 2004;350:1495-1504  PROVE-IT
9. Cannon CP, et al.; IMPROVE-IT Investigators. IMPROVE-IT trial: a comparison of ezetimibe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes after acute coronary syndromes.  2014 American Heart Association Scientific Sessions; November 15-19, 2014; Chicago, Illinois. Abstract LBCT-02.
10. O’Riordan M. IMPROVE-IT: ‘Modest’ benefit when adding ezetimibe to statins in post-ACS patients. November 21, 2014.
11. Prasugrel versus clopidogrel in patients with acute coronary syndromes. Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neumann FJ, Ardissino D, De Servi S, Murphy SA, Riesmeyer J, Weerakkody G, Gibson CM, Antman EM; TRITON-TIMI 38 Investigators. N Engl J Med. 2007 Nov 15;357(20):2001-15. Epub 2007 Nov 4.
12. Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, et al. (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361: 1045–1057  PLATO [PubMed]
13. Effect of platelet inhibition with cangrelor during PCI on ischemic events. Bhatt DL, Stone GW, Mahaffey KW, Gibson CM, Steg PG, Hamm CW, Price MJ, Leonardi S, Gallup D, Bramucci E, Radke PW, Widimský P, Tousek F, Tauth J, Spriggs D, McLaurin BT, Angiolillo DJ, Généreux P, Liu T, Prats J, Todd M, Skerjanec S, White HD, Harrington RA; CHAMPION PHOENIX  Investigators. N Engl J Med. 2013 Apr 4;368(14):1303-13. doi: 10.1056/NEJMoa1300815. Epub 2013 Mar 10.
14. Dabigatran versus warfarin in patients with atrial fibrillation.  Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L; RE-LY Steering Committee and Investigators.  N Engl J Med. 2009 Sep 17;361(12):1139-51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30. Erratum in: N Engl J Med. 2010 Nov 4;363(19):1877.
15. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.  Manesh R. Patel, M.D., Kenneth W. Mahaffey, M.D., Jyotsna Garg, M.S., Guohua Pan, Ph.D., Daniel E. Singer, M.D., Werner Hacke, M.D., Ph.D., Günter Breithardt, M.D., Jonathan L. Halperin, M.D., Graeme J. Hankey, M.D., Jonathan P. Piccini, M.D., Richard C. Becker, M.D., Christopher C. Nessel, M.D., John F. Paolini, M.D., Ph.D., Scott D. Berkowitz, M.D., Keith A.A. Fox, M.B., Ch.B., Robert M. Califf, M.D., and the ROCKET AF Steering Committee for the ROCKET AF Investigators  N Engl J Med 2011; 365:883 891  September 8, 2011 DOI: 10.1056/NEJMoa1009638  N Engl J Med 2011;365:883-891  Free Full Text | Web of Science | Medline
16.  Apixaban versus warfarin in patients with atrial fibrillation.   Granger CB, Alexander JH, McMurray JJV, et al.   Aristotle  N Engl J Med 2011; 365:981-992September 15, 2011DOI: 10.1056/NEJMoa1107039  Free Full Text | Web of Science | Medline
17. Table trials
18.  Excel: trials